KMID : 0620920010330020064
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Experimental & Molecular Medicine 2001 Volume.33 No. 2 p.64 ~ p.68
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The protective effect of Amomum xanthoides extract against alloxan-induced diabetes through the suppression of NFkB activation
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Byung Hyun Park/Byung Hyun Park
Jin Woo Park
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Abstract
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This study was undertaken to investigate the preventive mechanism of Amomum xanthoides extract against the development of alloxan-induced diabetics of mice. Pretreatment of mice with A. xanthoides extract via intraperitoneum prevented alloxan-induced hyperglycemia and hypoinsulinemia in a dose dependent manner. Histological examination of pancreatic tissue from A. xanthoides extract treated mice showed that the islet cells remain unaffected by alloxan treatment. NF¥êB activation in the pancreas 30 min after alloxan injection (60 mg/kg, iv), as assessed by an electrophoretic mobility shift assay, was not detected in the mice pretreated with A. xanthoides extract. These results suggest that NF¥êB activation may be one of the critical determinant in the progression of the disease. Considering the preventive effect of A. xanthoides extract from alloxan-induced diabetics development, these results may provide the possible therapeutic value of A. xanthoides extract for the prevention of diabetes mellitus progression.
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KEYWORD
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Amomum xanthoides, alloxan, NFkB, diabetes,
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